GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2111504 | 1 | rs58591218 | chr19:32890782 | ZNF507 | chr19:32836514-32878571:+ | 0.32 | 7.85 | 2.85E-14 | Bipolar disorder |
| THCA | cis | rs12435908 | 1 | rs58602070 | chr14:65849242 | LOC645431 | chr14:65877313-65879335:- | -0.36 | -4.69 | 3.51E-6 | Ischemic stroke |
| THCA | cis | rs9309473 | 1 | rs58603761 | chr2:73726605 | ALMS1P | chr2:73872046-73912692:+ | 0.69 | 10.91 | 6.53E-25 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs58603761 | chr2:73726605 | NAT8 | chr2:73867850-73869537:- | 0.36 | 5.67 | 2.48E-8 | Metabolite levels |
| THCA | cis | rs9309473 | 1 | rs58603761 | chr2:73726605 | TPRKB | chr2:73956957-73964517:- | -0.16 | -4.22 | 2.91E-5 | Metabolite levels |
| THCA | cis | rs2157926 | 1 | rs58638862 | chr7:87524860 | DBF4 | chr7:87505544-87538856:+ | -0.25 | -3.86 | 0.000131 | Bone mineral density (spine) and age at menarche |
| THCA | cis | rs3796352 | 1 | rs58660500 | chr3:53086573 | RFT1 | chr3:53122503-53164470:- | 0.64 | 7.59 | 1.65E-13 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs3796352 | 1 | rs58660500 | chr3:53086573 | TMEM110 | chr3:52867139-52931547:- | 0.32 | 3.77 | 0.000184 | Immune reponse to smallpox (secreted IL-2) |
| THCA | cis | rs2243480 | 1 | rs58669269 | chr7:65951953 | CCT6P1 | chr7:65216092-65228661:+ | 0.44 | 6.73 | 4.96E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs58669269 | chr7:65951953 | CRCP | chr7:65579805-65619551:+ | -0.26 | -3.81 | 0.000156 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs58669269 | chr7:65951953 | RABGEF1 | chr7:66093890-66276446:+ | 0.63 | 7.63 | 1.32E-13 | Diabetic kidney disease |
| THCA | cis | rs726288 | 1 | rs58704470 | chr10:81729390 | LOC219347 | chr10:81805991-81838949:- | 0.51 | 5.21 | 2.88E-7 | Rheumatoid arthritis |
| THCA | cis | rs7714584 | 1 | rs58717741 | chr5:150284936 | LOC134466 | chr5:150310000-150326146:- | 0.45 | 6.01 | 3.62E-9 | Crohn's disease |
| THCA | cis | rs7714584 | 1 | rs58717741 | chr5:150284936 | ZNF300 | chr5:150273964-150284391:- | 0.16 | 3.43 | 0.000668 | Crohn's disease |
| THCA | cis | rs4888671 | 1 | rs58729171 | chr16:77786018 | NUDT7 | chr16:77756411-77776153:+ | 0.36 | 4.91 | 1.25E-6 | Obesity-related traits |